WHY SHOULD ANYONE BELIEVE FACEBOOK ANYMORE?

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Facebook CEO and founder Mark Zuckerberg testifies during a US House Committee on Energy and Commerce hearing on April 11, 2018.

SAUL LOEB/AFP/GETTY IMAGES

IF THERE IS one message Facebook has been trying to send to the world in 2018, it’s that the company understands it needs to rethink the way it operates. Facebook says it understands that it must better police the content that appears on its platforms. And as a result of the Cambridge Analytica scandal early this year, Facebook says it must be more effective in how it protects user data, more transparent about all the data it collects, and more clear about who has access to the data. CEO and cofounder Mark Zuckerberg said fixing Facebook was his project for 2018, and he said earlier this year that he was dedicating enough resources to the problem that we should expect to see tangible progress as we approached 2019.

Facts have proven to be inconvenient things for Facebook in 2018. Every month this year—and in some months, every week—new information has come out that makes it seem as if Facebook’s big rethink is in big trouble. The billions the company is spending to fix itself, along with slowing advertising growth in Europe and North America, have stalled revenues. Its once high-flying stock price is down 35 percent. Well-known and well-regarded executives, like the founders of Facebook-owned Instagram, Oculus, and WhatsApp, have left abruptly. And more current and former employees are beginning to question whether Facebook’s management team, which has been together for most of the last decade, is up to the task.

Technically, Zuckerberg controls enough voting power to resist and reject any moves to remove him as CEO. But the number of times that he and his number two, Sheryl Sandberg, have overpromised and underdelivered since the 2016 election would doom any other management team. And so for the first time in Facebook’s storied history as a public company, employees, investors, and users are beginning to wonder if the only way to solve Facebook’s current spate of problems is to replace the two of them.

Just since the end of September, Facebook announced the biggest security breach in its history, affecting more than 30 million accounts. Meanwhile, investigations in November revealed that, among other things, the company had hired a Washington firm to spread its own brand of misinformation on other platforms, including borderline anti-Semitic stories about financier George Soros. Just two weeks ago, a cache of internal emails dating back to 2012 revealed that at times Facebook thought a lot more about how to make money off users’ data than about how to protect it.

Now, according to a New York Times investigation into Facebook’s data practices published Tuesday, long after Facebook said it had taken steps to protect user data from the kinds of leakages that made Cambridge Analytica possible, the company continued to sustain special, undisclosed data-sharing arrangements with more than 150 companies—some into this year. Unlike with Cambridge Analytica, the Times says, Facebook provided access to its users’ data knowingly and on a greater scale.

Some companies, like Microsoft and its Bing search engine, had access to all of a Facebook user’s friends without consent. Apple devices had access to the contact numbers and calendar entries of people who had changed their account settings to disable all sharing. Spotify and Netflix had the ability to read users’ private messages. The search engine Yandex was one of the companies with special access, even though it has long been suspected of having special ties to the Kremlin. The Times had access to users’ friend lists for an article-sharing application it had discontinued in 2011—access that lasted into 2017. (The company told its reporters that it was not obtaining any data.) Apple, Netflix, Spotify, and Yandex told the Times they were unaware that Facebook granted them such broad access.

There have been murmurings all year over whether Congress might pass new data protection laws, akin to the GDPR in Europe, or whether the FTC would fine Facebook for violating its 2011 consent decree with the agency. Now it would not be a stretch to wonder if both those things aren’t imminent when the new Congress convenes in January. Already—earlier Wednesday—the attorney general for the District of Columbia decided to sue Facebook for alleged data misuse stemming from Cambridge Analytica. It’s likely to have company in that effort.

Facebook told the Times that no data was mismanaged or misused, that the data was all available publicly, that it considered its partners to effectively be part of Facebook and therefore subject to the same strict rules of conduct, and that as a result it was not in violation of any statutes or its consent decree with the FTC.

Facebook posted further comment in a blog post, authored by Konstantinos Papamiltiadis, Facebook’s director of developer platforms and programs: “Today, we’re facing questions about whether Facebook gave large tech companies access to people’s information and, if so, why we did this. To put it simply, this work was about helping people do two things. First, people could access their Facebook accounts or specific Facebook features on devices and platforms built by other companies like Apple, Amazon, BlackBerry, and Yahoo. These are known as integration partners. Second, people could have more social experiences—like seeing recommendations from their Facebook friends—on other popular apps and websites, like Netflix, The New York Times, Pandora, and Spotify,” Papamiltiadis wrote.

“We’ve been public about these features and partnerships over the years because we wanted people to actually use them—and many people did. They were discussed, reviewed, and scrutinized by a wide variety of journalists and privacy advocates. But most of these features are now gone. We shut down instant personalization, which powered Bing’s features, in 2014 and we wound down our partnerships with device and platform companies months ago, following an announcement in April.

“Still, we recognize that we’ve needed tighter management over how partners and developers can access information using our APIs. We’re already in the process of reviewing all our APIs and the partners who can access them.”

Zuckerberg and his executives are such masters of this kind of sincere apology, it should have a special name like “apolozuck” (or perhaps just “zucked”). It’s truly rhetoric as art. “We’re sorry. We’re as upset as you are. But that thing you are angry at us about happened a few years ago, and we’ve fixed the problems. They happened because we were trying to make Facebook better for you. But we now see how it left your data vulnerable to bad things too. We care more about your data and your privacy than anyone. It won’t happen again. We promise.”

What has enabled them to deliver these apologies, year after year, was that these sycophantic monologues were always true enough to be believable. The Times’ story calls into question every one of those apologies—especially the ones issued this year.

All year long, Facebook has encouraged the world to believe that a Cambridge Analytica–style data leakage couldn’t happen anymore—that, as Zuckerberg told lawmakers in April, users had “complete control” over what happened to their data. Two weeks ago, after those scheming emails Zuckerberg exchanged with executives about data-sharing arrangements were released by the UK Parliament, Zuckerberg said in a Facebook post that they were taken out of context.

Except it appears now that Facebook has had all manner of data-sharing relationships it hasn’t been telling the world about. “We’ve never sold anyone’s data,” Zuckerberg wrote in his post, and has insisted at various other times this year. But Zuckerberg saying that Facebook has never sold user data is an answer only an engineer could love. It is technically correct, but practically false. Sure, Facebook has never given other companies user data in exchange for cash. But it’s quite obvious to the world now that Facebook for a long time has been giving user data to other companies, in exchange for other equally or more valuable things.

There’s a simple takeaway from all this, and it’s not a pretty one: Facebook is either a mendacious, arrogant corporation in the mold of a 1980s-style Wall Street firm, or it is a company in much more disarray than it has been letting on. Think about almost everything bad that’s happened to Facebook since the 2016 election: Russian interference, Cambridge Analytica, data sharing, astroturfing. Facebook could have kept all of them from becoming scandals—or at least becoming as big of a scandal—had it just leveled with the world when it had the chance. The fact that it hasn’t suggests that it didn’t want to, or it is just not well managed enough to pull it off.

It’s hard to process this without finally realizing what it is that’s made us so angry with Silicon Valley, and Facebook in particular, in 2018: We feel lied to, like these companies are playing us, their users, for chumps, and they’re also laughing at us for being so naive.

We’d expect such deceptions from banks, oil companies, car makers, or tobacco firms. But companies like Facebook built their brands by promising something different. They told us, “It’s not about the money and the power of being a billionaire and running one of the richest companies on the planet—it’s about making the world a better place, making it more open and connected.” And we fell for it hook, line, and sinker.

Americans are weird about their tycoons. We have a soft spot for success, especially success from people as young as Zuckerberg was when he started Facebook. But we hate it when they become as super-rich and powerful as he is now and seem accountable to no one. We’ll tolerate rogues like Larry Ellison, founder and CEO of Oracle, who once happily admitted to hiring investigators to search Bill Gates’ trash. Ellison makes no effort to hide the fact that he’s in it for the money and the power. But what people despise more than anything is what we have now with tech companies in Silicon Valley, especially with Facebook: greed falsely wrapped in sanctimony.

Facebook gave the world a great new tool for staying connected. Zuckerberg even pitched it as a better internet—a safe space away from the anonymous trolls lurking everywhere else online. But it’s now rather debatable whether Facebook is really a better internet that is making the world a better place, or just another big powerful corporation out to make as much money as possible. Perhaps the world would be happier with Zuckerberg and Facebook, and the rest of their Silicon Valley brethren, if they stopped pretending to be people and businesses they are not.

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HatTipcanstockphoto53073149  Fred Vogelstein

 

Don’t Worry Be Happy

Some Reading Music

 

Bobby was sitting on the plane at Cleveland waiting to fly to Chicago, when a guy took the seat beside him. The guy was an emotional wreck…pale, hands shaking in fear. “What’s the matter, afraid of flying?” Bobby asked.

“No, it’s not that. I’ve been transferred to Chicago. The people are crazy there, right? Lots of shootings, gangs, race riots, drugs, poor schools, and the highest crime rate in the USA.”

Bobby replied, “I’ve lived in Chicago all my life. It’s not as bad as the media says. Find a nice home, go to work, mind your own business, and enroll your kids in a nice private school. I’ve worked there for 14 years and never had the slightest trouble.”

The guy relaxed and stopped shaking and said, “Oh, thank you. I’ve been worried to death, but if you’ve lived and worked there all those years and say it’s OK, I’ll take your word for it. What do you do for a living?”

“I’m a tail gunner on a Budweiser truck…”

 

It Snowed Last Night

 

snoman

 

This is a reap host because nobody recognized the gunny. Can you do it without using google?

New G.I. Benefit

Three old servicemen were waiting in the veteran’s affairs office to apply for a lump-sum bonus to which they had been entitled.

The V.A. officer came in and addressed them all.

“Gentlemen, the V.A. has decided that all bonuses will be given commensurate with physical measurements taken from the applicant.To be fair however, the applicant gets to decide the measurement used.”

The first man, a sailor stand up and says. “I want my measurment to be from the top of my head to the tip of my toes.”

The V.A. officer takes a tape measure and measures this distance, and announces, “Five foot eleven..your bonus will be five thousand, one hundred and ten dollars.”

The second man, a pilot in the USAF stand up and says, ” I want to be measured from the tips of my outstretched arms.”

The V.A. officer measures this and announces, “Six feet, two inches..your bonus will be six thousand, two hundred dollars.”

The third man, and old Marine Gunny stands up and says “You can measure me from the tip of my cock to my balls.”

Sgt Carter


The V.A. man is confused and says “Are you sure that’s the measurment you want to use?”

“Damn straight” says the grizzled old Marine, and drops his drawers.

The V.A. officer kneels before him and places the end of the tape measure on the tip of the soldier’s penis and extends it downward until he reached where the man’s testicles would have been.”

“Where are your balls?” the V.A. man asks.

“Vietnam” says the Marine.

SPACEX HAS LAUNCHED A PIECE OF ART INTO ORBIT

A SpaceX Falcon 9 rocket launched on December 3 from Vandenberg Air Force Base, north of Santa Barbara, California, its payload includes 64 small satellites from 34 organizations and 17 countries, each having paid launch broker Spaceflight Industries a hefty fee to be blasted 350 miles up and released into low earth orbit.

Most of these satellites are destined to carry out some utilitarian purpose, be it communications, observation, or science. But there is one small satellite among them that aims to do nothing more than entice people around the world to enact a primal, atavistic urge: to look up at the night sky and wonder what’s out there.

It’s April, and that satellite’s creator, the artist Trevor Paglen, is sitting in the lobby of a Hampton Inn in West Covina, California, 20 miles east of downtown LA, explaining the rationale behind the project he’s calling the Orbital Reflector.

“The point for me really was to create a kind of catalyst for looking at the sky and thinking about everything from planets to satellites to space junk to public space and asking, ‘What does it mean to be on this planet?’” says Paglen, who has come to California to witness some crucial prelaunch tests on his creation. “It’s a timeless question in some ways, but the content of the question is always changing.”

Paglen has described the project, which was undertaken in partnership with the Nevada Museum of Art in Reno, as “the first satellite to exist solely as an artistic gesture.” As gestures go, it’s not cheap—its budget of $1.5 million was funded by the museum, private donors, and a Kickstarter campaign—but it’s certainly true to its name.

Once in orbit, it will deploy a 100-foot-long, 5-foot-wide balloon made of high-density polyethylene coated with titanium dioxide powder that will reflect light back to earth, making it as visible to the naked eye as a star in the Big Dipper, a work of public art streaking across the night, visible to anyone who looks up into a clear sky at the right time, and trackable via the project’s website and a partnership with the Starwalk 2 app.

“The goal has been to build this out like it’s the exact opposite of every other satellite,” says Paglen, who has a long history of art projects that chart the dark world of government surveillance. Where other satellites might spy or photograph or measure, his will be defiantly, whimsically useless. It will remain in the sky for at least two months and then will burn up in the atmosphere on re-entry. “It’s a way to do an artwork that exists at and thinks about the scale of the planet.”

Website to Track the Orbital Reflector.

A QUIET WAR RAGES OVER WHO CAN MAKE MONEY ONLINE

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HOTLITTLEPOTATO
 

OVER THE PAST year, two popular forums for men who identify as involuntary celibates, or incels, have been banned by Reddit and a domain registrar in response to members’ history of toxic misogyny and celebrating violence against women. Now some of these men are trying to turn the tables. Members of the incel community—including the official Twitter account for incels.is, a central hub for adherents—have joined with other men’s rights activists, using the content policies of online payment companies such as PayPal as weapons to block female pornographic actors and sex workers from making or spending money online.

The campaign is called the “ThotAudit,” in reference to the derogatory term “thot,” which stands for “that ho over there.” It began over the Thanksgiving holiday as a grassroots effort to intimidate sex workers and women who sell access to private pornographic social media accounts by reporting them to the Internal Revenue Service for tax evasion—without evidence of wrongdoing. But it quickly morphed into a battle over who has the right to make money on the internet.

The harassers are taking advantage of user reporting tools made available by companies like PayPal, Venmo, and CirclePay, in an attempt to force their targets offline and freeze their finances. The tactic has far-reaching implications beyond adult entertainment. Foreign governments and other groups have abused the policies to silence opponents on platforms like Twitter and Facebookfor years. Attacking through the payment processors is a new wrinkle on that approach.

When Lily Adams, an actor and model who sells access to her pornographic photos and videos, first noticed the ThotAudit movement gaining traction Saturday evening, she took to Twitter, calling it a witch hunt. Within one minute, a ThotAuditor flagged her account and tweeted that she had been added “to the review list for Monday morning.” By Monday, Adams’ PayPal account had been terminated. In an email to WIRED, Adams said that she had approximately $526 in her PayPal account at the time, and that the company told her it would hold the funds “indefinitely.”

“The feeling of being attacked from all corners is definitely frustrating,” said Adams. By the end of the day, she had been banned from every cash app, and she wasn’t alone. Another pornographic actor and model, who goes by the name Haven Graye online, was banned by Venmo the day after the ThotAudit campaign began. ”118 men called me a prostijew, kike and sen[t] me pictures of people burning,” she told WIRED via direct message. On Twitter, dozens of other sex workers experienced similar harassment and expressed outrage over being banned from multiple online payment service providers, including PayPal, Cash App, and Circle Pay. Many of the women claimed to have lost access to hundreds of dollars, as most payment companies absorb whatever funds were stored in the reported account.

Participants in the harassment campaign openly discussed tactics and specific attacks in r/ThotAudit, a public subreddit. On Sunday, one user detailed a popular alternative to reporting sex workers to the IRS, which the user said was too slow and dangerous: “Find the thots paypal email, send them money, and then report them for selling goods against paypals services … It’s against Paypal’s rules to solicit digital sexual content. All of their funds will be locked pretty quickly.” Users also posted comprehensive “thot auditing field guides,” including a continually updated list of tens of thousands of potential targets, and detailed instructions for getting sex workers banned from PayPal, Venmo, Cash App, Amazon Pay, Stripe, Circle Pay, Snapchat, and Kik.

PayPal did not respond to multiple requests for comment, but its website states that it prohibits PayPal users from buying or selling “sexually oriented digital goods or content delivered through a digital medium.” Venmo, which is owned by PayPal, also forbids users from using the service for “certain sexually oriented materials or services.” Square prohibits using its payment services for “adult entertainment oriented products or services” in any medium, as do Amazon Pay, Stripe, and Circle Pay. None of the companies responded to requests for comment.

Organizers of the campaign against sex workers are trying to capitalize on the increased vigilance of social media companies and payment providers in policing their platforms. Historically, those networks censored individual posts or banned individual accounts sparingly, not wanting to be seen as regulating speech. More recently, though, partly in response to concerns that they are inciting violence or encouraging hate speech, networks such as Facebook and Twitter are acting more aggressively.

The new approach extends beyond Facebook and Twitter to the network of largely unseen companies that make the commercial web function—web-hosting companies, domain registrars, security providers, and payment processors. After a gunman allegedly killed 11 people in a Pittsburgh synagogue, a social media platform he frequented was driven offline for nearly a week when its payment service providers, web host, and domain registrar dropped contracts with the company. A similar fate befell the primary forum for incels in the wake of the related Toronto terror attack carried out by a self-professed incel, and neo-Nazi site the Daily Stormer after Charlottesville. However, most cases are not as clear cut.

Consider the controversies around the ASMR community. ASMR, or autonomous sensory meridian response, is a tingling feeling beginning in the neck or back experienced by some people when they listen to soft or strange sounds—like a woman whispering into a mic, a dry paintbrush on a canvas, or crinkling paper. A booming, highly profitable community has emerged on YouTube creating content that caters to those with ASMR, where (usually female) YouTubers try to trigger the response in viewers. The YouTubers often are dressed in strange costumes or act out scenes that could be viewed as pornographic or sexual in nature. That’s prompted PayPal, which prohibits the sale of digital “sexually oriented” content like pornography, to ban a number of popular ASMR creators, effectively cutting them off from a significant revenue stream.

In the attacks by incels and their allies, activists on Twitter, Reddit, and 4chan have created automated programs to streamline the process of identifying, reporting, and harassing their targets. One program, called the ThotBot, includes the profiles of more than 20,000 alleged sex workers from several social media platforms that include a link to a PayPal account. “Search for bios with paypal in it, if they get banned paypal takes ownership of all the money on the account and it inevitably will be taxed as well,” the creator of the tool wrote in a tweet. In a later message, he claimed that one user of his program reported more than 100 profiles to PayPal.

A later version of the ThotBot claimed to draw from over 100,000 profiles, and was disabled by GitHub a few days after it was created. A spokesperson from GitHub confirmed that the repository and dataset were removed for violating the company’s harassment policies. In a direct message to WIRED, the creator of this ThotBot said the program aims for the “total excommunication or extermination of whores in society,” adding that he wants them to face the death penalty.

r/ThotAudit, which described itself as a community for “Right Wing Tax Squads,” had nearly 2,000 subscribers before it was banned Tuesday evening. In a statement to WIRED, a Reddit spokesperson said the subreddit had been banned for violating Reddit’s policies prohibiting content that “threatens, harasses, or bullies, or encourages others to do so.” In a sign of how extreme the group’s tactics are, 4chan, the anything-goes forum infamous for being a hotbed of depravity and toxicity, also banned numerous threads created by self-proclaimed members of the Right Wing Tax Squad.

Many of the harassment campaign’s biggest supporters have long complained of being censored by social media platforms and internet infrastructure companies. On Twitter, incels.is, a large online forum for incels, has championed efforts to have sex workers banned from several platforms, while denouncing companies like Reddit and the .ME Registry for doing the same to its accounts. The MGTOW community—a more extreme offshoot of the incel movement whose adherents consider women subhuman—has been in turmoil for two weeks after YouTube banned ads on many MGTOW-related videos and channels, cutting off those users’ revenue streams. Yet many members of the movement helped instigate the ThotAudit.

Rose, a financial dominatrix who was targeted by the ThotAudit harassment campaign, says digital payment companies like PayPal have long had rules in place prohibiting sex-work-related transactions and frequently suspend the accounts of sex workers whenever it is made aware of their existence. Financial domination is a fetish where the submissive sends gifts—in this case, cash via online payment—to the dominant partner. In a message to WIRED, Rose said many men threatened to report her to PayPal on Tuesday, but she had already been banned by PayPal for using it for sex-work-related transactions. To evade the ban, Rose accepts payments through Circle App, Cash App, Google Pay, and Amazon gift cards.

Organizers of the campaign against sex workers continue to refine their tactics. As of Wednesday evening, much of the discussion among harassers on platforms like Twitter centered around streamlining reports to payment services providers like Cash App, PayPal, and Venmo. In one thread on the subject, an active member of the ThotAudit campaign detailed tactics he said would expedite the reporting process, including spamming webforms with multiple reports, including links to illustrate the breach of the company’s terms of service, and threatening to report the breach to the media if the company did not immediately ban the sex worker.

“This complaint has been logged and will be sent in a package to the media along with others in an ongoing story about how payment processors are ‘selective’ about which terms they act upon,” read the message. “I trust PayPal will do the right thing…”

HatTipcanstockphoto53073149  wired.com

MEET THE CAROUSING, HARMONICA-PLAYING TEXAN WHO JUST WON A NOBEL FOR HIS CANCER BREAKTHROUGH

I identify with carousing, playing the harmonica and being a Texan — I. Adolph Oliver Bush

Chance favors the prepared mind. — Louis Pasteur

JAMES ALLISON LOOKS like a cross between Jerry Garcia and Ben Franklin, and he’s a bit of both, an iconoclastic scientist and musician known for good times and great achievements. He also doesn’t always answer his phone, especially when the call arrives at 5 am, from an unfamiliar number.
So when the Nobel Prize committee tried to reach Allison a few weeks ago to inform him he’d been awarded the 2018 Nobel Prize in medicine, Allison ignored the call. Finally, at 5:30 am, Allison’s son dialed in on a familiar number to deliver the news. The calls have not stopped since.
Allison’s breakthrough was the discovery of a sort of secret handshake that cancer uses to evade the immune system, and a means to block that handshake—what the Nobel committee hailed as “a landmark in our fight against cancer,” which has “revolutionized cancer treatment, fundamentally changing the way we view how cancer can be managed.” (Allison’s co-recipient was Tasuku Honjo of Kyoto University.) Advances in cancer typically come in 50-year increments; the science that Allison and Honjo helped advance, cancer immunotherapy, has made a generational leap seemingly overnight.

Adapted from The Breakthrough: Immunotherapy and the Race to Cure Cancerby Charles Graeber.

TWELVE PUBLISHING

Until very recently we’ve had three main methods for treating cancer. We’ve had surgery for at least 3,000 years. We added radiation therapy in 1896. Then in 1946, chemical warfare research led to the use of a mustard gas derivative to kill cancer cells. Those poisons were the foundation for chemotherapy.

These “cut, burn, and poison” techniques are currently estimated to be able to cure cancer in about half of the people who develop the disease. And that’s remarkable, a true medical accomplishment. But that leaves the other half of cancer patients. Last year, in the United States alone, that translated to nearly 600,000 people who died of the disease.

The fight was never fair. We’ve been pitting simple drugs against creative, mutating versions of our own cells, trying to kill the bad ones while sparing the good ones, and making ourselves sick in the process. And we’ve been doing that for a very long time.

But now we have added a new and very different approach—one that doesn’t act directly on cancer, but rather acts on the immune system. And that’s the breakthrough.

THE IMMUNE SYSTEM has evolved over 500 million years into a personalized and highly effective natural defense against disease. It is a complex biology with a seemingly simple mission: to find and destroy anything that’s not supposed to be in our bodies.Hundreds of millions of immune cells circulate throughout the body, searching out and destroying invaders that make us sick and body cells that have become infected, have mutated, or have become defective—cells like cancer.Which raises the question: Why doesn’t the immune system fight cancer already, the way it fights even the common cold?

For more than 100 years, medical researchers puzzled over that question. Most concluded that the immune system and cancer simply had nothing to say to each other. The argument was that since cancer is a normal body cell gone rogue, it is too much a part of us to ever trigger an immune response. Cancer immunotherapy was condemned as a quaint if simplistic idea based on high hopes and bad science. But despite the mounting mockery of the larger scientific community and dwindling research funds, a handful of immunotherapy researchers continued to believe—and continued searching, decade after decade, for the missing piece of the cancer immunity puzzle, a factor that prevented the immune system from recognizing and attacking cancer cells.

The stakes could not have been higher. If such a missing piece could be found, it would radically reshape our scientific understanding of both ourselves and disease and possibly revolutionize medicine on a scale not seen since the invention of vaccines. It might allow us to finally unleash our immune system, enabling it to recognize and attack cancer the way it does other diseases. It might even pave a new road to the cure. For the tens of millions more diagnosed with cancer each year, the race to find the missing piece of the cancer-immunity puzzle was literally a matter of life and death.

But despite the occasional glimmer in the darkness, generations of researchers had tried and failed to find this missing factor. Nobody could even say for certain that such a such a piece existed. And certainly nobody would have guessed that it would be discovered by a hard-living, harmonica-playing Texan who hadn’t even been looking for it.

THE STRETCH BETWEEN 1965 and 1973 were peak years if you were young and musical in Austin, when the little university town was just beginning its metamorphosis into the tech and freak capital of a cowboy state—Texas enough to two-step, hippie enough to do it stoned, and smart enough to work the newly relocated tech mills of Texas Instruments, Motorola, and IBM. Jim Allison fit right in.

Allison initially thought he would go to medical school but soon realized he was more interested in research and set out to earn a PhD in biochemistry.

COURTESY OF JIM ALLISON

He had outgrown his hometown of Alice, Texas, when the local high school failed to offer an advanced biology class that dared mention Charles Darwin. He turned to correspondence courses from the University of Texas at Austin. and after graduation he enrolled full-time, a 17-year-old bound to be a country doctor like his dad. Back then, the 2018 Nobel Prize in medicine wasn’t even a twinkle in the young Texan’s eye.

If you sold beer in Austin and had a surface flat enough to put a bar stool on, you were a music club, and Jim Allison played the blues harp well enough that he was in demand. He could sit in at the honky-tonks in town or play for Lone Stars in Luckenbach, where the new breed of outlaw country players like Willie Nelson and Waylon Jennings roamed the earth. Either way it was a lot of fun; premed, meanwhile, wasn’t proving to be that interesting. Allison wasn’t drawn to memorizing what others had found out. He wanted to arm himself with skills to do the finding himself, so in 1965 he switched tracks and traded memorization for a laboratory, working with enzymes toward a biochemistry PhD.

Enzymes are natural organic chemicals that make stuff happen. The enzymes Allison was studying happened to break down a chemical that fueled a type of mouse leukemia; inject a mouse with this specific enzyme and the enzyme destroyed the cancer fuel. His goal was to figure out the biochemistry of how those enzymes did their job.

In the experiment, once the enzyme eventually robbed the tumor of all its fuel, the tumor went necrotic and “disappeared.” Allison wanted to know where it went. Allison says. His curiosity led him to his first glimpse of a biology he would eventually redefine, and the first tenuous steps toward a generational breakthrough in the war against cancer.

Allison knew the disease intimately. He’d been just a kid when he lost his mom to it, had held her hand as she went, not even knowing what the disease was or why she had burns, only knowing she was gone. He’d lose most of his family that way eventually, and though he’d never say it out loud, and wouldn’t even much voice it to himself, in the back of his mind killing cancer would always be the one potential, practical outcome of his otherwise pure scientific research. Allison would follow his curiosity like a north star, wandering for decades, but heading home all the while.

The dead tumors in his mouse cages hadn’t just disappeared by magic, of course—it was biology. The human body sheds old, dead cells (a mass roughly equal to our body weight each year) the way trees shed leaves, and for essentially the same reason. The process (called “apoptosis,” from the Greek for “to fall away”) allows fresh daughter cells to take their place. The spring cleaning is carried out by hungry, blobby Pac-Man cells in our blood—part of a 500 million-year-old personal defense force that Allison’s textbooks called the innate immune system.

Today, aspects of our immune system still remain a mystery, but when Allison began his studies it hadn’t really even been explored, a sort of deep-ocean ecosystem in the human body. “New” aspects of the immune system, like the hunter-killer T-cells, were barely on the radar yet (Allison’ s college professor thought they were “too weird” evolutionarily to really exist). But some of the older aspects of the defenses in our bloodstream had been worked out, especially those of the innate immune system, which works much the same in sea sponges as it does in humans.

The ancient players of the innate immune system are charismatic and deceptively straightforward. They also happen to be big enough to be seen wiggling and eating under the microscope. That includes amoeba-like cells adept at squeezing between body cells and patrolling our perimeter (inside and out, we have a surface larger than a doubles tennis court), looking for what shouldn’t be there and killing it.

Some of the innate immune cells are small, blobby smart patrollers called dendritic cells. Others are similar-looking but larger blobby characters called macrophages (literally, “big eaters”). Most of what they eat are those retired body cells—normal cells that have hit their expiration date and politely self-destructed, through apoptosis. They also eat bad guys.

Macrophages have an innate ability to recognize simple invaders. Most are the usual suspects of disease—the bacteria, fungi, parasites, and viruses that evolved right alongside us for millennia. These foreign, or “non-self,” cells are recognizable as foreign because they look different—that is, the fingerprint of chemical arrangements of proteins on their surfaces is different. Macrophages look for anything they recognize as foreign, then grab and gobble it.

From his reading in the library, Allison knew that researchers had found these blobby amoeba-like cells to be more than just garbagemen; they were also frontline reporters bringing back updates from the constant battle against disease. When they found something interesting and foreign, they carried pieces of those strange, non-self proteins (or “antigens”) back to the lymph nodes, to show them around like wanted posters. (Lymph nodes are like Rick’s in Casablanca. Good guys, bad guys, reporters and soldiers, macrophages, dendritic cells, T and B cells, and even diseased cells, everyone goes to Rick’s.) The information triggered other cells in the adaptive immune system to ramp up into a massive clone army in specific response.

Allison knew that was basically how vaccines worked—by presenting the body with dead samples of a disease that it might encounter later. This introduction triggers the immune system to build up forces against anything that looks like that sample. Then later, if the live disease does show up, an immune army will be waiting for it.

Now, Allison wondered if something like that was happening in his mouse cages, too

He’d killed the tumor. The mouse macrophages were gobbling up the mutant cells and clearing them out. In the process, they were surely carrying back those distinctive mutant proteins and showing them to the killer cells of the adaptive immune system. And wasn’t that sorta how a vaccine worked?

So, Allison wondered, did that mean his experiment had, in a roundabout way, vaccinated his mice against this specific form of blood cancer? Were they now “immune” to this cancer?

“Just for the hell of it, I was setting up another experiment, and I decided that since I had these mice that were cured—who were just sitting there, eating—I would inject them with the tumor again, but not treat them with the enzyme this time, and see what happened,” Allison remembers. He hadn’t asked permission, he didn’t write a protocol, nothing. He simply shot from the hip. And what happened was … nothing.

“They didn’t get tumors,” Allison says. “I went back and injected them with 10 times as much, and they still didn’t get tumors. I injected them with another five times more, and they still didn’t get tumors! Something was happening here,” Allison says. “Something amazing!”

“It was great,” Allison says of his time as a researcher at MD Anderson Cancer Center outside of Houston. “The camaraderie—nobody expected any payback for anything. They did it because it’s what you did, you know? It was heaven.”

THE UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER/COURTESY OF JIM ALLISON

As a casual one-off, the experiment hadn’t really proved anything. (“People talked about doing it in humans, you know, just taking your own tumor and mashing it up somehow and injecting it back, but it doesn’t really work that easily.”) But it had provided Allison his first glimpse of the mystery and potential of the immune system and its most recently discovered component, the T cell. His professor was only half wrong—they did exist, but they were, in fact, weird. Good weird, Allison thought. They were killers, some of them, but there were other types that “helped” complex immune responses, making it possible to somehow be prepared to recognize and kill diseases that the human body had never encountered before. And, really, there was no telling how much we didn’t yet know.

Simply put, this was the most interesting thing Jim Allison had ever come across. So he decided to switch tracks, again, and study that.

BY 1973, AFTER eight years spent getting his BA, MS, and PhD in Austin, Allison wanted to stretch his legs and find somewhere new and “first-rate” for his immunology research, and that took him 1,300 miles west into California and a postdoc program at the prestigious Scripps Institute. He was married now, doing lab work by day and playing harmonica with a country-western band a couple of nights a week. “Our band got pretty famous in what was called the North County,” Allison says. “People think it’s all like LA or something, but that part of California’s pretty redneck.”Fights were brief but frequent. “Usually, it’d start because one cowboy that’s doing a two-step would swing too widely and bump into a guy, and the guy would say, ‘Don’t do that again.’ But, that’s just the way the guy danced, you know? He danced big. So it happened again. Pretty soon there’s beer and fists everywhere.”Allison was the only one in the band with a day job, but playing with full-time musicians put him quickly into the local music scene. Plus, Allison was the guy with the VW microbus. “So we’d go to these parties. There was one up the road in Del Mar—we walk in, I don’t know anyone. It was a pretty magnificent party by the way,” Allison says, “with Waylon Jennings and Tammy Wynette doing a few songs each, then Willie Nelson—turns out it was a celebration of his Red-Headed Stranger album.” The two Texans got to talking and partying, and next thing Allison’s got Willie and some of his band in the back of the microbus, on the way to open-mic night at the Stingray.

“Man, they sold a lot of beer that night,” Allison says. Willie had taken the mic, asking, “You all mind if I stand in and play a few?” then played for four hours. “I never had to pay for another one in that bar again,” Allison says. Afterward he took the band back to the hotel. “Yeah, that was good,” Allison says. “And somehow we managed to avoid getting arrested.”

Meanwhile, Scripps wasn’t really working out the way he’d imagined. “I was purifying proteins and sequencing them and all this stuff, working on the key molecules of the immune system,” he says, “but it really wasn’t immunology.” Allison was interested in systems. “But we were discouraged from what the older guys called, you know, ‘model building.’ Like, ‘Don’t build models, just do your work. Don’t think.’ Yeah. It was very frustrating. I figured, if this is what science is, I don’t like it.” The cutting edge of cancer therapy might look very different had Allison quit the field right there. Instead, he went home and got lucky.

Back in Texas, the MD Anderson Cancer Center was opening a new outpost lab near the town of Smithville. “Yeah, it was pretty weird.” Allison says. “Some economic stimulus thing from the governor, on donated land and with state money. And it was in the middle of an 18-acre state park. They’d just set up some lab buildings and hired six faculty members to go out there.”

The idea was to fund a team to study carcinogenesis—how cancer starts. But in reality, Allison soon discovered, they pretty much had free rein.

“Yeah, that was the weird thing at the time, because after they started this thing, the MD Anderson president changed. The new guy came in and said, “What do you do? What the hell is that?” You know? So they kind of just forgot about us and pretty much left us alone.”

This was Allison’s kind of place. His colleagues were bright, enthusiastic scientists his own age—the oldest were in their thirties—who worked late, helped each other with their experiments, kept beer in the lab for ones that ran overnight, and pooled intellectual resources without ego or credit getting in the way. “It was great,” Allison says. “The camaraderie—nobody expected any payback for anything. They did it because it’s what you did, you know? It was heaven.”

The setup was sweetened by a total lack of teaching or administrative responsibilities, a Norton Commando 850 motorcycle, and enough NIH and NCI grant money to pursue what Allison was really interested in—the T cell.

“It was a fantastic time in science because immunology had just been this poorly understood field,” he says. “I mean, everybody knew we had an immune system, because there were vaccines. But nobody knew much about the details of anything.”

One of the things nobody knew was how a T cell recognized a sick cell in the first place. By now it was understood that T cells killed off normal body cells that had become sick or infected. But exactly how a T cell “saw” that sick body cell, how it recognized the distinctively foreign sick cell proteins (or “antigens”) on the cell’s surface, was still a stone-cold mystery. Allison read every academic paper he could find on the topic, then read the papers cited in them.

There were plenty of theories about how a T cell recognized antigens. Most assumed that each T cell had a unique type of receptor (a specific arrangement of proteins extending from the cell surface) that recognized a specific antigen expressed by a sick cell, homing in and fitting something like a key into a lock.

That was a reasonable theory, but nobody had actually found one of the receptors. If they existed, there should be a lot of them, scattered among all the yet-uncounted proteins that stuck out from the T-cell surface (there are so many that new ones are given numbers, like newly identified stars). Those “receptor” proteins would be molecules built in some sort of double-chain-like configuration. Several labs were convinced that it would look just like it did on another denizen of the adaptive immune system that “sees” antigens, the B cells. Which, Allison thought, was stupid.

“People from Harvard and Johns Hopkins and Yale and from Stanford were already claiming they had a molecule that was the T cell receptor,” Allison says. “Most of them, because B cells make antibodies, figured that in T cells the receptor had to be an antibody-like thing, too.”

Whatever it looked like, if you could find it, in theory you could manipulate it. Control the T-cell receptor and you might control what the immune system’s killing machine targeted. The result could have massive implications for humanity, and a massive name—and maybe even a Nobel Prize—for whoever found it.

B CELLS AND T cells are both part of the adaptive immune system. They look so similar that they cannot be distinguished under an optical microscope—part of the reason they’d gone undiscovered for so long. But B and T cells would turn out to be distinct types of immune cells, which see and attack foreign or non-self cells in very distinct ways.Allison didn’t believe that T cells were just a cell-killing version of B cells, a sort of killer-B. He believed that if T cells existed (they did) and were different from B cells (they were), then those differences were the point. The T cell wasn’t just more of the same—it was a unique cell type that did a unique job, and accomplished it in a unique way, through a unique biology.

The race to clone the T-cell receptor protein gene was intense. “I mean, everybody realized there was a Nobel Prize at the end of it,” Allison says. “Everybody was scrambling, man.”

SCOTT DALTON

“We didn’t have a library to speak of in Smithville,” Allison remembers, but he had access to an excellent library down the road, thanks to having finagled an adjunct appointment with the main MD Anderson campus in Houston and a newly restored ’54 Mercedes for the back-and-forth. “I’d go and Xerox big stacks of shit and then read it,” he says. He was looking to better understand the T cell receptor. But what Allison was reading in the academic journals didn’t really make sense to him.

“Yeah, when that happens, the fact that it doesn’t make sense is either their fault or your fault,” Allison laughs. Naturally, his first assumption was that it was his fault. “I’d think, ‘I’m an idiot. I can’t understand this.’” Allison says. “Then, I thought, ‘No, they’re idiots. They don’t understand what they’re talking about!’” Then he’d drive back out to the library and copy another stack.

All the reading and wondering came together one night while Allison was in Houston sitting in on a lecture by a visiting Ivy League immune researcher. Something just clicked. “I said, ‘I think I know a shortcut to finding the T-Cell receptor.'”

Suddenly it seemed so obvious: If Allision could rig up a way to compare B cells and T cells, devise a lab experiment that put one against the other and let their redundant surface proteins cancel each other out, the receptor should be the molecule that didn’t cancel out. Essentially, he was looking for a needle in a haystack, and his idea was to set fire to the haystack and sift the ashes—or as Allison puts it, “pick it out of the weeds.” Whatever was left would be the needle he was looking for.

He gunned the Merc back to the Smithville lab and got to work. The idea was relatively simple, but the steps were numerous, and Allison had to make all the assays himself, which was tedious work. “The assays were so crude,” Allison says. “The end point involved holding a piece of film up and trying to guess which circle was bigger out of 100, you know? Then doing that with maybe 1,000 different films. People laughed at us. I’m really surprised that it worked.”

And yet, it did work. “It was a success, the very first time,” he says. “So now I’ve got a thing that’s on T cells but not on B cells, not on any other cells— so, that’s gotta be the T-cell receptor!”

He showed that the receptor was a two-chain structure—an alpha and a beta chain, and he wrote it up in a paper.

Allison was hoping to be published by one of the leading peer-reviewed research journals. But nobody at Cell or Nature or any of the A-list, peer-reviewed journals was willing to publish the findings of this junior academic from Smithville, Texas. “Finally, I ended up publishing the results in a new journal called The Journal of Immunology.” It wasn’t Science or the New England Journal of Medicine, but it was in print, and in the world.

“At the end of the paper, I said, ‘This might be the cell antigen receptor, and here are the reasons why I think that it is the T-cell antigen receptor,’ and I just listed it out, all the reasons.” It was a bold announcement regarding the biggest topic in immunology. “And nobody noticed it,” Allison says. “Except in one lab.”

That lab was headed by eminent biologist Philippa “Pippa” Marrack at UC San Diego. Her lab (shared with her husband, John Kappler) hadn’t identified the T-cell receptor yet, but they had a scientific technique that could verify if Allison’s results were correct. Marrack reproduced Allison’s experiment and got an exact hit on the protein Allison had identified—and only on that protein. It was a shock, especially coming out of a lab Marrack had never heard of. Allison says she called and told him she was organizing a Gordon Conference—elite, closed-door gatherings something like the Davos of science. She invited him to present at the meeting; Allison had a sense he was being invited into the big leagues.

The Gordon meeting helped put the brash young scientist on the academic map and won him an appointment as a visiting professor at Stanford University. It also gave him license to pursue the next intellectual milestone. Now that the T-cell antigen receptor had been identified and its two-chain molecular structure had been described, the race was on for the greater prize: the blueprints for those proteins, as encoded in genes in the T-cell DNA.

“At that point, people had just figured out how you could work with DNA and clone genes, so now, everybody was trying to clone this T-cell receptor protein gene,” Allison says. “It had been the holy grail of immunology for 20, 25 years, and nobody had solved it. There was this huge, ugly race for about three or four years. I mean, everybody realized there was a Nobel Prize at the end of it. Everybody was scrambling, man.” The experience provided a valuable lesson to the young immunologist. “I mean, it got ugly. Ugly. But I met some really good people there too, some fine people,” Allison says. “So I sorta learned who was who.”

“Anyway, we cloned a lot of stuff,” Allison says. “But none of it was right.” Other teams wound up decoding the T-cell receptor genes. “Yeah. Anyway, we failed. A guy named Mark Davis at Stanford actually cloned the beta chain gene. Then, later on, his lab and his wife cloned the alpha chain gene. In the meantime, though, I was in Irv Weissman’s lab and I got a call one day to give a seminar at Berkeley. Berkeley, you know; it was like, ‘Wow.’

“It was kind of controversial because I hadn’t been at the big labs,” Allison says. “I hadn’t been at Harvard. I lacked the pedigree of most faculty at places like Berkeley.” Which was why it blew his mind two weeks later when Berkeley offered him a full-time job, covered by a healthy grant from the Howard Hughes Medical Institute. Allison would have a lab and postdoc salaries, and he could research whatever he wanted. He didn’t need to teach, and the money might last forever with no strings. His only obligation was to occasionally give a presentation on his progress.

“Then when you came up for review, it was pretty bad,” Allison says. “They would have 50 of the top scientists in the world in the room. You would give a 25-minute talk, and it was 25 exactly. When minute 25 came, it was ‘Stop. Questions?’ It was really frightening. Literally, sometimes the night before I’d just be in the bathroom throwing up.”

Much had been discovered about T cells in the decade since their discovery. Now it was widely accepted that there were different kinds of T cells, with different specialties for coordinating an immune response against disease. Some “helped” immune response by sending out chemical instructions, via cytokines, like a quarterback calling plays. Others, the killer T cells, killed infected cells one-on-one—usually by chemically instructing those cells to commit suicide.

These processes, and more, were set in motion only when a T cell was “activated.” Activation is the beginning of the adaptive immune response to disease; until then, the T cells are just floating around and waiting. So what activated T cells? What made them start mobilizing against disease?

“We thought that the T-cell antigen receptor was the ignition switch,” Allison says. That was the natural assumption.

It was only after they’d identified the T-cell receptor that they realized, nope, that wasn’t quite right either. They could get the T-cell receptor to “see” the foreign antigen of a sick cell; they clicked together like lock and key. They could make that fit. But it wasn’t enough to turn on a T cell. It wasn’t the “go” signal that ignited the immune response.

After all the work that had gone into decoding the T-cell receptor, this might have been a frustrating development; instead, it only deepened the mystery. “When I learned that, I said, ‘Oh, wow, this is cool. T cells are even more complex,’ you know?” Allison remembers. “It just added to the puzzle. It made it more fun.”

If keying the T-cell receptor with the corresponding antigen wasn’t the only signal needed to turn on a T cell, that meant there had to be another molecule, maybe several, required to activate the T cell, what’s known as “co-stimulation.” Maybe the T cell required two signals—like the two keys for a safe deposit box, or how, when starting a car you need to key the ignition and also press the gas pedal to make it go. But where was the T cell’s gas pedal? Three short years later, they found it, another molecule on the T-cell surface called CD28. (CD stands for “cluster of differentiation,” which is sort of like calling it “a thing that’s clearly different from the other similar things around it”.)

CD28 was definitely a second signal required for activating T cells; that is, they’d discovered that T cells could not activate without it. That was an important discovery, but as Allison and other researchers quickly realized, it also wasn’t that simple. Presenting the right antigen key to the T-cell receptor and co-stimulating CD28 did start up the T cell, but when they did that in mice models, the T cell often just stalled out. It was as if they’d found the key to the ignition and the gas pedal, but a third signal was still necessary to make the T cell go. So now they went hunting for that.

One of Allison’s postdoctoral students, Matthew “Max” Krummel, compared the structure of the protein CD28 to other molecules, looking for something similar in a sort of computerized book of molecule mug shots—“the gene bank, that’s what we called it at the time,” Allison says. The idea was that if you found a molecule that looked similar, maybe it did similar things and was related, evolutionarily.

Krummel soon found another molecule with a close family resemblance to the part of CD28 that stuck out of the cell, the receptor part. The molecule had recently been identified, named, and numbered. It was the fourth cytotoxic (cell-killer) T-immune cell (lymphocyte) identified in the batch, so Pierre Goldstein, the researcher who’d found it, called it cytotoxic T-lymphocyte-associated protein #4— or CTLA-4 for short. (A few decades later, these letters would be on the license plate of Allison’s convertible Porsche.)

Early on, Allison read every scientific paper he could find on T-cell receptors. “I’d think, ‘I’m an idiot. I can’t understand this.’” he says. “Then, I thought, ‘No, they’re idiots. They don’t understand what they’re talking about!’”

THE UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER/COURTESY OF JIM ALLISON

Meanwhile, researchers Jeffrey Ledbetter and Peter Linsley were working on the same third-signal problem at the Bristol-Myers Squibb research campus in Seattle. Finding the protein signal was one thing, but the point was understanding what it did. Blocking a signal (with an antibody that binds to it and basically prevents it from being used, like crazy-gluing a keyhole) and observing the result is a common method. “Linsley made an antibody to block CTLA-4,” Allison recalls. The group quickly published a paper, concluding that CTLA-4 was a third “go” signal, another gas pedal on the T cell that had to be activated for immune response.

Having another researcher beat them to the anti-CTLA-4 antibody was disappointing. It was especially disheartening to Krummel, who had just spent three years working on the antibody as his intended thesis project. But Allison decided to proceed with more CTLA-4 experiments anyway. There was always more to learn—and besides, Allison wasn’t totally convinced that Linsley et al. had really solved the T-cell activation mystery. “I knew there were two ways you can get something to go faster,” Allison says. “One is to press on the gas pedal. The other is to take off the brake.”

Allison says Linsley’s group had only devised experiments consistent with CTLA-4 being another “go” signal, essentially a second CD28. “I said, ‘Let’s do the experiments consistent with CTLA-4 giving an off signal.’ Sure enough, that’s what we found out. CTLA-4 was an off signal.”

Jim Allison is a master of the Texas-sized understatement. Behind his simple statement of his lab’s new finding lies a discovery that has profoundly shifted our scientific understanding of how immunity works—and sometimes doesn’t—and how we can change those rules to turn the tables on cancer.

ALLISON’S LAB NOW had a fairly complete picture of the steps required for T-cell activation against disease. First, the T cell needed to recognize the sick cell by its unique protein fingerprint; in other words, it needed to be presented with the antigen that matched up with its T-cell receptor. Usually it was a dendritic cell or macrophage that did that presenting. Binding to that antigen was like turning the key in an automobile ignition.

The other two signals (CD28 and CTLA-4) were like the gas pedal and brake on the car. CTLA-4 was the brake—and it was the more powerful of the two. You could press both (and in experiments, Krummel found that was a crude way of controlling the activation rate), but if you floored both, the brake overruled the gas pedal and the T cell wouldn’t go, regardless of everything else.

Or, more accurately, enough stimulation of CTLA-4 and immune response stalled out, regardless of how much the T cell was being triggered by a sick cell antigen.If all this sounds complicated, it’s because it is, on purpose. Allison’s lab had discovered an elaborate safety mechanism, an aspect of the larger framework of checks and balances that prevents the immune system from going into overdrive and attacking healthy body cells. Each safety is a sort of fuse that gets tripped if a trigger-happy T cell is programmed to target the wrong antigen, such as ones found on normal body cells. It was a way of repeatedly asking Are you sure about this? before T cells turned into killing machines.Proper triggering of immune response against pathogens is what keeps you healthy. However, pedal-to-the-metal immune response against healthy self cells is autoimmune disease.

The double-check, double-signal mechanism of T-cell activation would turn out to be only one of many redundancies and fail-safe feedback loops built into immune response. Those “checkpoints” on T-cell activation hadn’t been guessed at before. But now Allison’s lab and, simultaneously, the lab of Jeff Bluestone at the University of Chicago had found one of those checkpoints.

Bluestone was focused on ways of placing this new discovery in the context of organ transplants and diabetes, tamping down unwanted immune response. But Allison had a different idea where he’d like to stick it

Biology was interesting, diseases weird and fascinating, immunology cool. But cancer, Allison admits, “pissed me off” personally. Allison’s lab had always been dedicated primarily to pure immune research. But now Jim Allison had another experiment in mind, and an intellectual path to an emotional destination. As it happens, that road also eventually led to the Nobel Prize.

ALLISON WROTE THE experiment out in late summer and gave it to his new postdoc, Dana Leach, who, he says, had “done some tumor stuff.” “I said, ‘I want you to give some mice tumors and then inject them with this CTLA-4-blocking antibody. Give other mice tumors but no anti-CTLA-4, and let’s see what happens.’” In November, Leach came back with the results: The mice that got anti-CTLA-4 had been cured of cancer. The tumors had disappeared. In the mice that didn’t have CTLA-4 blocked, the tumors kept growing.

Allison was stunned—this wasn’t what experimental data looked like. “According to the data, it was a ‘perfect’ experiment, 100 percent alive versus 100 percent dead,” Allison says. “Jesus, I mean, I was expecting—something. But this was 100 percent. Either we’d just cured cancer or we’d really screwed up.”He needed to do it over again. “We had to,” Allison says. And they needed to start immediately—such experiments take a couple of months. But it was Thanksgiving, and Leach wasn’t willing to give up his planned European trip over Christmas break, not for a bunch of mice.Allison told him to just set up the experiment again. “Right now, inject all the mice,” he said, “then go do whatever you’re going to do.”

He told the postdoc to just label the cages A, B, C, and D. “I said, ‘I’ll measure the mice. Don’t tell me anything.’” Allison would do the grunt work and check the results for each cage, but until it was over, he wouldn’t know which group was which.

“It was really harrowing,” Allison says. He’d come in every day and see that the tumors in cage A seemed to be getting bigger. He’d measure each tumor with calipers and mark the results on his gridded paper, then move to cage B and find the same thing, mice with growing tumors. Same story in cage C and cage D. There were a lot of mice, a lot of numbers, and they were all on the same track. It was 100 percent failure.

Had his break-happy postdoc screwed up this experiment too? Allison felt he was moving backward. Finally, on Christmas Eve he was in the lab, staring at four cages of mice, all with steadily growing tumors. “I said, ‘Fuck—I’m not going to measure these anymore. I need to take a break from this.’”

But by the time Allison returned four days later, the situation in the cages had changed dramatically. In two of the cages the mouse tumors were now shrinking. In the other two cages the tumors continued to grow. When he unblinded the experiment’s cages, he was sure. It had taken time for the immune response to kick in, much like it does with a vaccination, but it had happened. Day by day, and surprisingly quickly, the trend continued to the end; it was just as before—100 percent dead versus 100 percent alive and tumor-free, a perfect experiment.

He hadn’t consciously known where he was going with all of this experimentation. Now, suddenly, they had arrived at a result and a biological mechanism. Maybe Allison and his lab had cured cancer in mice, one more time. Or perhaps they had just found a piece of the cancer immunity puzzle, one that might make sense of decades of confusing data. CTLA-4 was a safety checkpoint built into the body to help prevent the immune system from attacking the body or a developing fetus. Tumors survive and thrive, shielded by these built-in safety mechanisms on T cells, which effectively put the brakes on the body’s immune response against them. That was cancer’s survival trick, or one of them. At least, it was in mice. But if Allison could block it in mice, maybe he could block it in people.

The breakthrough wasn’t what was in the cages; it was the new view of the world the data revealed. It doesn’t usually happen in science like it does in the movies, the eureka moment, a new understanding in an instant. But this was it. EUREKA! T cells could recognize cancer, but these inhibitory pathways stifle a complete T cell response, and you could block that.

What else was possible? That question, and the hope it engendered—that was what mattered. And that was the breakthrough.

Allison didn’t do it all, and he didn’t do it alone. But there’s little doubt that the now 70-year-old scientist’s work tipped the balance in a 100-year scientific debate. Allison’s work cracked open the door; subsequent breakthroughs have kicked it wide. The result is a fundamental course correction in the direction of cancer research and treatment and a groundswell of scientific talent and R&D dollars being funneled into a formerly discredited field of pursuit.

The war on cancer is not over; we have not achieved a full and total cure, and so far the handful of cancer immunotherapy drugs available have demonstrated robust and durable results in a minority of patients. But we have undeniably turned a corner in our understanding of the disease—what many scientists believe to be a “penicillin moment” in our quest for the cure.

The CTLA-4-blocking drug Ipilumimab, approved by the FDA in 2015, was the first of a new class of drugs called “checkpoint inhibitors” and the beginning of what researchers refer to as a tsunami of new cancer treatments. The pace of progress is staggering, such that we now recognize that what Allison discovered is not only the end of that 100-year scientific mystery, but also the beginning of a new chapter in medicine. Already, new therapies such as CAR-T have essentially wiped out some forms of cancer; the newest checkpoint inhibitors have turned stage-four metastatic death sentences into full remission. This work has only just begun. And while it’s hopeful, it’s not hype.

Jim Allison returned home to Texas, where he works with his wife and fellow prize-winning cancer immunotherapist Padmanee Sharma at MD Anderson in Houston. His work continues to travel the world, and change it. Allison still plays blues harp—he considered backing Willie Nelson on stage a few years ago to have been a lifetime highlight, before he found out about the Nobel—and he regularly hears from former cancer patients whose lives were changed or saved by his work. He sees them in the halls and on planes; they are everywhere. Not only because they now number in the hundreds of thousands, but because they are us.

And, his wife says, Jim cries, every damn time.

 


 

Adapted from the book THE BREAKTHROUGH: Immunotherapy and the Race to Cure Cancer. Copyright (c) 2018 by Charles Graeber. Reprinted by permission of Twelve/Hachette Book Group, New York, NY. All rights reserved.

HatTipcanstockphoto53073149  wired dotcom

Getting Screwed 

A guy walks into the bar of a restaurant and goes to the bartender and asks “How much for a beer?”

The bartender replies “A nickle”.

The customer, completely amazed, orders a beer then asks the bartender “Well then how much for a NY sirloin, with side of mashed potatoes and salad, and an entire cheesecake for desert?”

The Bartender replies “a quarter”.

The guy, still amazed, then orders everything and after he is done eating his meal, then says “Wow, this place is amazing, I really wish I could meet the owner of this place”.

The bartender then says “Oh well, he’s upstairs in his office with my wife”.

The guy looks all confused, then asks “What is he doing upstairs in his office with your wife?”

The bartender said “The same thing I’m doing to his business down here”.


 

New G.I. Benefit

Three old servicemen were waiting in the veteran’s affairs office to apply for a lump-sum bonus to which they had been entitled.

The V.A. officer came in and addressed them all.

“Gentlemen, the V.A. has decided that all bonuses will be given commensurate with physical measurements taken from the applicant.To be fair however, the applicant gets to decide the measurement used.”

The first man, a sailor stand up and says. “I want my measurment to be from the top of my head to the tip of my toes.”

The V.A. officer takes a tape measure and measures this distance, and announces, “Five foot eleven..your bonus will be five thousand, one hundred and ten dollars.”

The second man, a pilot in the USAF stand up and says, ” I want to be measured from the tips of my outstretched arms.”

The V.A. officer measures this and announces, “Six feet, two inches..your bonus will be six thousand, two hundred dollars.”

The third man, and old Marine Gunny stands up and says “You can measure me from the tip of my cock to my balls.”

Sgt Carter


The V.A. man is confused and says “Are you sure that’s the measurment you want to use?”

“Damn straight” says the grizzled old Marine, and drops his drawers.

The V.A. officer kneels before him and places the end of the tape measure on the tip of the soldier’s penis and extends it downward until he reached where the man’s testicles would have been.”

“Where are your balls?” the V.A. man asks.

“Vietnam” says the Marine.


Tom’s Scrotum

The pastor asked if anyone in the congregation would like to express praise for answered prayers.

Suzie Smith stood and walked to the podium.

She said, “I have a praise.

Two months ago, my husband, Tom, had a terrible bicycle wreck and his scrotum was completely crushed. The pain was excruciating and the doctors didn’t know if they could help him.”

(You could hear a muffled gasp from the men in the congregation as they imagine the pain that poor Tom must have experienced.)

“Tom was unable to hold me or the children,” she went on, “and every move caused him terrible pain.”

We prayed as the doctors performed a delicate operation, and it turned out they were able to piece together the crushed remnants of Tom’s scrotum, and wrap wire around it to hold it in place.”

(Again, the men in the congregation cringed and squirm uncomfortably as they imagined the horrible surgery performed on Tom.)

“Now,” she announced in a quivering voice, “thank the Lord, Tom is out of the hospital and the doctors say that with time, his scrotum should recover completely.”

(All the men sighed with unified relief.)

The pastor rose and tentatively asked if anyone else had something to say.

A man slowly stood up and walked just as slowly to the podium.

He said, “I’m Tom Smith.” The entire congregation held its breath.

“I just want to tell my wife — the word is sternum.”


 

Why do some people laugh when someone farts and others don’t?
A fart is an asshole telling a joke in a language that only other assholes can understand.
 

Effects of THC on the Balance of Seabirds. 

When I was a biology student I conducted a study on the balance in sea birds with a specific focus on Royal Terns.

I proposed that giving measured doses of THC (marijuana) and observing their flight patterns would give some clutch to the problems of balance in 3D space.

This proposal being given in a more liberal era, I got the funding.

I filled out thousands of forms, set up a lab with a ready supply of terns, and proceeded on my way.

After a year of diligent work, groveling monthly before the review committee to get my stipend, and living with drugged terns, I completed my study.

With trembling hands, I delivered my 347-page report, complete with charts and graphs, to the review committee.

The august body perused my study, asking penetrating questions and reducing me to jello. Finally, the department head spoke.

The light reflected off her horn-rimmed glasses as she stared down at me.

“There is a lot of good work here,” she said. “But we can’t accept this report. You have detailed marvelously the effects of THC on terns but you forgot one essential step: you have no control group.”

I turned pale and said, “You don’t mean…”

“Yes. I’m afraid so. You left no Tern unstoned.”


Melania was awakened by a strange noise in the middle of the night. “Wake up, Donald,” she whispered, “I think there are thieves in the house.” “Wha….,” said Donald sleepily, “You woke me for this? They’re not in the House, they’re in the Senate.”


 

 


The family of an elderly Arab gentleman have searched everywhere for a nursing home for him. At last they find one – a Jewish home. Some days pass, and his son calls to visit. “How is it here?” he asks.

“It’s great”, the old man replies. “Do you know, they address everyone here by their title, no matter how long it is since they practiced their vocation. There’s a conductor who hasn’t stood in front of an orchestra for 30 years, but they still call him Maestro. And a doctor who hasn’t lifted a stethoscope for 20 years, but is still addressed as Doctor Cohen. An academic who retired 25 years ago is still called Professor.”

“What about you?” the son asks.

“It’s the same with me”, replies the old man. “I haven’t had sexual intercourse for 40 years, but they still call me the fucking Arab.”


I’m Off…

To my new job as a test pilot for preparation H